Understanding Chewable Sildenafil Formulations

And while all three of the medications share a small set of common potential side effects — headache, nasal congestion, and dyspepsia — most adverse side effects happen because of the medications inhibiting other PDE families aside from PDE5.35 Sildenafil and vardenafil collaterally inhibit PDE1 and PDE6. Tadalafil, meanwhile, doesn’t cause that kind of collateral effect, but it does collaterally inhibit PDE11.6 This provides some explanation for why these medications differ in the side effects they're most likely to cause. As the active ingredient in Viagra, sildenafil is probably the most common and certainly the longest-studied ED medication on the market today.

• Sildenafil is a medication used primarily to treat erectile dysfunction.
• Chewing sildenafil can alter how quickly it takes effect.
• Swallowing sildenafil whole is recommended for proper absorption.
• Chewing sildenafil may lead to unpredictable drug absorption.
• Sildenafil should be taken with water, ideally on an empty stomach.
• Altering the form of sildenafil can increase the risk of side effects.
• The standard dose of sildenafil varies from 25mg to 100mg.
• Consult a healthcare provider before modifying sildenafil intake.
• Do not chew sildenafil if it is in its original tablet form.

It’s the one that started them all, the only one introduced in the 20th century; if you’re old enough, you may remember Bob Dole as a spokesman for it following his presidential campaign in the late ‘90s. Like vardenafil, sildenafil is an as-needed medication. You’ll take it 30-60 minutes before sexual activity may occur, and after that waiting period, the medication will be effective for a period of 4-6 hours.

• Sildenafil improves erectile function by enhancing blood flow.
• Chewing sildenafil tablets is not an approved method of administration.
• Use sildenafil only as prescribed by your doctor.
• Do not double-dose if an effect is not immediate.
• Be aware of possible side effects like flushing or stomach upset.
• Sildenafil should not be taken with certain heart medications.
• Store sildenafil in a cool, dry place away from children.
• Combining sildenafil with recreational drugs can be dangerous.
• Seek medical attention for prolonged erections or severe side effects.

On the one hand, the fact that it’s the longest-studied ED medication can give people some peace of mind, and it’s still the first path that many prescribing doctors explore with patients.

What Are PDE5 Inhibitors?

As BlueChew’s medications are all PDE5 inhibitors, they all temporarily prevent PDE5 from doing what it normally would do in your body… which makes it useful to understand what PDE5 ordinarily does. You may or may not have heard of the chemical, nitric oxide (NO). Some people take dietary supplements to increase NO in their bodies, typically with goals involving exercise performance, sexual performance, or general cardiovascular health. This is because NO, vascularly downstream of where it is released in the body, causes the conversion of GTP (guanosine triphosphate) into cGMP (cyclic guanosine monophosphate). cGMP relaxes the smooth muscles in the walls of blood vessels, which is what causes them to widen — something called vasodilation.4 So, NO can promote increased blood flow.

But sublingual and dissolving sildenafil aren’t in the United States

When it is released vascularly upstream from the spongy tissues of the penis, NO leads to more cGMP in those tissues, which enables the increase in blood flow and accumulation of blood there, causing an erection.5 What causes an erection to stop, meanwhile, is PDE5; when the body feels that it’s time for an erection to end, PDE5 is released to bind to the cGMP, causing smooth muscles in the blood vessels to return to normal.6 This means less blood flow to the penis, and the erection goes away. Inhibiting PDE5 is an effective way to allow many (but not all) men with ED to get erections strong enough for the sexual activity they want. And the reason these treatments don’t cause spontaneous erections is that arousal is still necessary for the brain to signal to the cavernous nerve (a nerve in the penis) to release NO there.6 (Remember, NO has the aforementioned effects vascularly downstream of where it is released.) None of the PDE5 medications that BlueChew offers are completely selective for PDE5. In other words, they can inhibit other families of PDE as well. To the limited extent that they do collaterally inhibit other PDE families, they can produce different side effects corresponding to those PDE families and what their normal jobs are in our bodies. On the other hand, years of research also reveal that sildenafil seems capable of causing certain side effects that a couple newer options like vardenafil sildenafil film tablet and avanafil likely won’t. Avanafil — the active ingredient in Stendra and the newest PDE5 for ED — is a relatively costly medication offered by Hims but not BlueChew.

Product	Dosage	Quantity + Bonus	Price
Kamagra Polo	100mg	12 Pills	60.21€ 57.34€	Buy
Kamagra	100mg	60 + 4 Pills	201.34€ 191.75€	Buy
Kamagra Polo	100mg	272 + 12 Pills	622.94€ 593.28€	Buy
Kamagra Oral Jelly	100mg	63 + 7 Sachets	224.18€ 213.50€	Buy
Viagra Generic	100mg	20 Pills	45.58€ 43.41€	Buy
Kamagra Soft Tabs	100mg	84 + 4 Pills	233.05€ 221.95€	Buy
Kamagra Polo	100mg	32 Pills	125.88€ 119.89€	Buy
Viagra Generic	150mg	30 + 2 Pills	72.32€ 68.88€	Buy
Viagra Generic	150mg	180 + 10 Pills	236.46€ 225.20€	Buy
Kamagra Polo	100mg	84 + 4 Pills	244.49€ 232.85€	Buy

It’s the most selective PDE5 inhibitor and less likely to cause side effects.7 Sildenafil’s most common side effects are mild and include:8 Dyspepsia (discomfort in the upper abdomen caused by stomach upset) Vision changes (such as a blue-green tint, temporarily blurred vision, or difficulty with color perception) Side effects involving vision disturbances arise due to the fact that sildenafil also collaterally inhibits PDE6. Of course, this isn’t the purpose of taking sildenafil; the goal is to inhibit PDE5 in order to facilitate erections.

Society and culture

For some people, BlueChew’s ED medications are a non-starter — unsafe or unsuitable for underlying health reasons, as determined by a consulting medical professional. If you’re considered a good candidate for treatment, it means that you will be able to access some of the most effective, safe, and affordable ED treatments available. But that doesn’t mean you won’t experience a side effect, or maybe more than one. So, what are BlueChew’s side effects? Are they exactly the same for each treatment option?

What’s your relationship status?

What about the likelihood of experiencing them? Because so many people have asked us for clarification about the potential side effects of BlueChew, we’ve created this comprehensive guide to shed more light on this important subject. If you’re going to begin a new medication like the ones BlueChew offers, you should definitely know what side effects you could encounter — and when those side effects should prompt you to speak to a doctor. Thankfully, BlueChew side effects are usually mild, but the likelihood and nature of possible side effects varies by medication and is affected by dose. We’ll break it all down so that you can proceed in confidence or explore alternative treatment options. PDE6 isn’t associated with erections but, instead, with certain visual processing pathways. People who experience vision-related side effects often successfully avoid them in the future by switching to tadalafil.

Benefit	Explanation	User Satisfaction	Onset Time
Faster Absorption	Chewing enhances quick absorption in bloodstream	High	15-30 min
Increased Convenience	Easier to take without water	Very High	20 min
Better Discretion	No need for swallowing pills	Moderate	10 min

Switching to vardenafil sometimes solves this problem as well; though vardenafil also weakly inhibits PDE6, research indicates that men who experience vision-related side effects from sildenafil may avoid those side effects when using vardenafil.9 Also, these mild visual changes are not to be confused with a very rare but serious side effect (described later) involving total loss of vision in one or both eyes.

How to get SIL, VAR, & TAD through BlueChew

Some of these, such as vitamin D and folic acid, are even present at levels that studies indicate could be beneficial for men trying to address ED.37 38 Only a medical professional — like the kind affiliated with BlueChew or its competitors, or a doctor you’d see in a traditional office — can determine if you’re a safe sildenafil otc and suitable candidate for these medications. If you are, it means the medical professional has reviewed pertinent details about your medical history, health, and current medications and concluded that using one of these medications will likely help address your ED symptoms without posing a serious risk to your health. But if you are approved, it does not guarantee you’ll experience no side effects. In fact, side effects are not uncommon. Thankfully, they tend to be very mild, with few people discontinuing treatment because of them.

BlueChew ED Medications

In our surveying the landscape of available ED treatments — prescription medications, over-the-counter options like supplements, and various devices you’d use at home or in a clinical setting — none currently offer the same combination of effectiveness, safety, affordability, and convenience as the treatments BlueChew offers. To understand why BlueChew’s ED medications would cause side effects and also why those side effects would vary from drug to drug, it’s useful to know a few basic details of how the medications work. All of BlueChew’s medications are PDE5 inhibitors, a class that also includes relative newcomer avanafil (Stendra), which BlueChew does not yet offer. PDE5 stands for “phosphodiesterase type 5.” (You can see why people use the abbreviation.) Phosphodiesterases are a superfamily of enzymes that act as regulators of signals being sent within cells. As the number in PDE5 would suggest, there are numerous families of sildenafil tablets lp 100 mg phosphodiesterase that have been identified — 11, to be precise (PDE1 through PDE11) — and they all have different effects on the human body.3 Scientists further divide these families into subtypes and splice variants. It’s rare, but if it happens, seek medical attention.

Choosing Between the Two

BlueChew entered the landscape as a unique company — the first to provide chewable prescription treatments for ED online. Initially, this meant compounded versions of the active ingredients in Viagra and Cialis, which are sildenafil and tadalafil, respectively. But later, BlueChew introduced a third option: chewable vardenafil, the active ingredient in Levitra. BlueChew offers ED prescriptions through an online portal, allowing you to have medication delivered straight to your door wherever you live in the United States (as long as that isn’t North Dakota), without any physical doctor’s visit or trip to a pharmacy. While it may have been the first, BlueChew is no longer the only company to do all of this.

Related treatment guides

It’s among a widening group of providers offering compounded forms of well-studied prescription ED medications. These compounded drugs have the same therapeutic potency as traditional, brand-name pills. Dosages do vary from company to company, which is something we’ll outline later in this guide since it can affect the likelihood of side effects. The company recently introduced a daily version of its tadalafil chew. (Previously, only an as-needed version of tadalafil was available.) The main difference between daily and as-needed tadalafil prescriptions tends to be dosage, though BlueChew’s daily chew does include supportive supplemental ingredients. Whereas sildenafil and vardenafil are similar in molecular structure, tadalafil (the active ingredient in Cialis) is quite different from them.3 There’s a waiting period of about 30-60 minutes before a dose starts working, but tadalafil is a much longer-acting drug than either sildenafil or vardenafil. Because tadalafil remains active for 18-36 hours, it can be prescribed either as an as-needed medication or a once-daily medication. As-needed BlueChew tadalafil comes in 6mg or 9mg doses, while daily tadalafil from BlueChew is 9mg.